Recent Publications

 

Dahlmann, H. A.; Vaidyanathan, V. G.; Sturla, S. J. Investigating the Biochemical Impact of DNA Damage with Structure-Based Probes: Abasic Sites, Photodimers, Alkylation Adducts, and Oxidative Lesions. Biochemistry, 2009, in press.
 
 

 

Liu, X.; Moody, E. C.; Hecht, S. S.; Sturla, S. J.  Deoxygenated Phosphorothioate Inositol Phosphate Analogs: Synthesis, Phosphatase Stability, and Binding Affinity.  Bioorg. Med. Chem., 2008, 16, 3419-3427. 

Neels, J. F.; Gong, J.; Xiang, Y.; Sturla, S. J.  Quantitative Correlation of Drug Bioactivation and Deoxyadenosine Alkylation by Acylfulvene.  Chem. Res. Toxicol. 2007, 20, 1513-1519. 

Sturla, S. J.  DNA-Adduct Profiles: Chemical Approaches to Addressing Small Molecule-DNA Damage Current Opinion in Chemical Biology.  2007, 11, 293-299. 

Vaidyanathan, V. G.; Villalta, P. W.; Sturla, S. J.  Nucleobase-dependent Reactivity of a Quinone Metabolite of Pentachlorophenol.  Chem. Res. Toxicol., 2007, 20, 913-919. 

Gong, J.; Sturla, S. J.  A Synthetic Nucleoside Probe that Discerns a DNA Adduct from Unmodified DNA. J. Amer. Chem. Soc., 2007, 129, 4882-4883. 

Sturla, S. J.; Irwin, J. J.; Loeppky, R. N.; Mulvihill, M. J.; Searcey, M.  Chemistry in Cancer Research: A Vital Partnership.  ACS Chem. Biol. 2007, 2, 286-292.

Gong, J.; Vaidyanathan, V. G.; Yu, X.; Kensler, T. W.; Peterson, L. A.; Sturla, S. J.  Depurinating Acylfulvene-DNA Adducts: Characterizing Cellular Chemical Reactions of a Selective Antitumor Agent.  J. Amer. Chem. Soc., 2007, 129, 2101-2111. 

Gong, J.; Neels, J. F.; Yu, X.; Kensler, T. W.; Peterson, L. A.; Sturla, S. J.  Investigating the Role of Stereochemistry in the Activity of Anticancer Acylfulvenes: Synthesis, Reductase-Mediated Bioactivation, and Cellular Toxicity.  J. Med. Chem., 2006, 49, 2593-2599.

Hecht, S. S.; Huang, C.; Stoner, G. D.; Li, J.; Kenney, P. M. J.; Sturla, S. J.; Carmella, S. G. Identification of Cyanidin Glycosides as Potential Chemopreventive Constituents of Freeze-Dried Black Raspberries. Carcinogenesis, 2006, 27, 1617-1626.

Nguyen, T. N. T.; Bertagnolli, A. D.; Villalta, P. W.; Buhlmann, P.; Sturla, S.J. Characterization of a deoxyguanosine adduct of tetrachlorobenzoquinone: Dichlorobenzoquinone-1,N2-etheno-2’-deoxyguanosine.  Chem. Res. Toxicol.2005, 18, 1770-1776.